Just like other μ-opioid agonists, tapentadol may perhaps bring about spasms on the sphincter of Oddi, and it is for that reason discouraged for use in people with biliary tract disease for instance each acute and chronic pancreatitis. People who are immediate or extremely quick metabolizers to the CYP2C9, CYP2C19, and CYP2D6 enzymes may well not